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Numerous baby chicks in a plastic basket

These chicks are part of UC Davis' living library of poultry and avian genetics, which includes the talpid lines examined in this study.  (Mary Delany/UC Davis photo)

Chickens and human craniofacial birth defects

Each year, thousands of babies are born in the U.S. with craniofacial defects, from cleft lips and palates to more severe abnormalities of the face or head. Now new discoveries in chicken genetics and biology are shedding light on the basis of these abnormalities in both birds and humans.

The work, by a team including UC Davis animal science professor Mary Delany, was made possible by information from the chicken genome sequence and a stock of rare chicken lines kept at UC Davis. The findings appear in the August issue of the journal Development.

The researchers focused on a mutation of the gene named talpid2, known to be associated with a number of congenital abnormalities, including limb malformations and cleft lip or palate.


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